null

SMILES CN([C@H](CN1CCCC1)c1ccccc1)C(=O)Cc1ccc(Cl)c(Cl)c1

InChI Key InChIKey=AEJOEPSMZCEYJN-HXUWFJFHSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50007344   

TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataKi:  0.0400nMAssay Description:Inhibitory constant against human Opioid receptor kappa using [3H]-diprenorphine as radio ligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7VH4PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataKi:  0.0430nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]-diprenorphine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8SDJPubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataKi:  0.0440nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3G7FPubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataKi:  0.0540nMAssay Description:In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U69,593More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26H4GNGPubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataKi:  24nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3G7FPubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataKi:  24nMAssay Description:Inhibitory constant against human Opioid receptor delta 1 using [3H]diprenorphine as radio ligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7VH4PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataKi:  53nMAssay Description:Inhibitory constant against human Opioid receptor mu 1 using [3H]diprenorphine as radio ligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7VH4PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataKi:  53nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3G7FPubMed
TargetUrotensin-2 receptor(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataKi:  4.00E+3nMAssay Description:Binding affinity to human urotensin2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37NJPubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Tested for inhibitory concentration against [3H]U-69593 binding at sites of kappa-opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2513ZVFPubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in electrically stimulated mouse vas deferens (MVD) preparation.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7PFGPubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37NJPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of cytochrome P450 2D6 was determined using MAMC (7-methoxy-4-aminomethyl-coumarin) as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7VH4PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataEC50:  0.300nMAssay Description:Inhibitory constant against human Opioid receptor kappa using [3H]diprenorphine as radio ligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PR7VH4PubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human kappa opioid receptor transfected in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3G7FPubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.270nMAssay Description:Inhibitory activity against Opioid receptor kappa 1 in electrically stimulated guinea pig longitudinal ileal muscle (GPI) preparation.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7PFGPubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Adolor Corporation

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Tested for inhibitory concentration against [3H]DPDPE binding at sites of delta-opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2513ZVFPubMed
TargetMu-type opioid receptor(GUINEA PIG)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Tested for inhibitory concentration against [3H]DAMGO binding at sites of mu-opioid receptor in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2513ZVFPubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 6.90nMAssay Description:Compound was evaluated for the Opioid receptor kappa 1 affinity using guinea pig brain membranes.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27080CRPubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50007344((S)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 6.90nMAssay Description:Binding affinity against opioid receptor kappa, in guinea pig brain membrane, using [3H]bremazocine as the radioligand.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2028S53PubMed