null

SMILES C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1

InChI Key InChIKey=UYNVMODNBIQBMV-HRAATJIYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50007677   

TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))TBA
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H](+)-[3H]di-o-tolylguanidine from sigma2 receptor in rat liver membranesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Displacement of [3H]ifenprodil from recombinant human GluN2B expressed in mouse L(tk-) cell membranes incubated for 120 mins by microbeta scintillati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q261126QPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Displacement of [3H]ifenprodil from Glun2B receptor (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639SQVPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Institut für Pharmazeutische und Medizinische Chemie der Universität Münster, Corrensstra?e 48, D-48149 Münster, Germany.

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Displacement of [3H]ifenprodil from human NR1-1a/NR2B receptor expressed in Mouse L(tk-) cell membranes incubated for 120 mins by scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6856PubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-unlike-ifenprodil from recombinant human GluN2B expressed in L-M(TK-) cell membranes by competitive receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Munster

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  125nMAssay Description:Displacement of [3H]-(+)-Pentazocine from sigma1 receptor in guniea pig brain cortex membranes by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639SQVPubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Munster

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  125nMAssay Description:Displacement of [3H]-(+)-Pentazocine from sigma1 receptor in guinea pig brain homogenate incubated for 120 mins by solid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q261126QPubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  125nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin) by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ67W6PubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Munster

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  278nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))TBA
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  369nMAssay Description:Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in CHO-K1 cells incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  530nMAssay Description:Displacement of [3H]prazosin from alpha-1A adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))TBA
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi:  6.10E+3nMAssay Description:Displacement of [3H]RX821002 from alpha-2A adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))TBA
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))TBA
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to 5-HT2C receptor (unknown origin) incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 843nMAssay Description:Compound was tested for the binding affinity against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN155WPubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 525nMAssay Description:Antagonist activity at human GluN2B expressed in Xenopus laevis oocytes assessed as reduction in glutamate and glycine stimulated ion flux by two-ele...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6P14PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:Binding affinity against alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN155WPubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 2.31E+3nMAssay Description:Binding affinity against alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN155WPubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5N4S
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 843nMAssay Description:Tested for the Alpha-1 adrenergic receptor affinity in a standard radioligand binding assay with [3H]- prazosinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5N4S
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 843nMAssay Description:In vitro binding affinity against Alpha-1 adrenergic receptor using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6FJKPubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Institut für Pharmazeutische und Medizinische Chemie der Universität Münster, Corrensstra?e 48, D-48149 Münster, Germany.

Curated by ChEMBL
LigandPNGBDBM50007677((+)-threo 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Displacement of [3H]ifenprodil from human NR1a/NR2B receptor expressed in mouse L(tk-) cell membranes by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639SQVPubMed