null

SMILES CCOC(=O)C1(CCN(C)CC1)c1ccccc1

InChI Key InChIKey=XADCESSVHJOZHK-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50026752   

TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataKi:  412nMAssay Description:Displacement of [3H]-paroxetine from serotonin transporter (SERT)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23F4NVMPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataKi:  413nMAssay Description:Displacement of [3H]citalopram from serotonin transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN744PPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataKi:  413nMAssay Description:Inhibition of [3H]paroxetine binding to rat serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ59KQPubMed
TargetMu-type opioid receptor(GUINEA PIG)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataKi:  451nMAssay Description:Binding affinity of the compound against mu opioid receptor was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K073D5PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataKi:  920nMAssay Description:Inhibition of [3H]DAMGO binding to mu-opioid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ59KQPubMedDrugBank
TargetMu-type opioid receptor(Homo sapiens (Human))
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataKi:  920nMAssay Description:Binding affinity at mu-opioid receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN744PPubMedDrugBank
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataKi:  1.78E+4nMAssay Description:Displacement of [3H]WIN 35428 from dopamine transporter in Sprague-Dawley rat brain after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN744PPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataKi:  1.78E+4nMAssay Description:Inhibition of [3H]WIN-35428 binding to rat dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ59KQPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataKi:  1.78E+4nMAssay Description:Displacement of [3H]-WIN- 35,428 from dopamine transporter (DAT)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23F4NVMPubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity of the compound against Opioid receptor kappa 1 was determined in brain membrane preparations from male Hartley guinea-pigsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K073D5PubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataEC50:  700nMAssay Description:Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ2DXMPubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HDVPubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HDVPubMed
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CZ367FPubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of Opioid receptors with [3H]naloxone binding in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HD7XT0PubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of Opioid receptors binding by inhibiting specific [3H]naloxone binding by 50% in the presence of 100 mM NaClMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HD7XT0PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 7.59E+4nMAssay Description:Inhibition of human ERG channel in HEK293 cells by voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542PTBPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 324nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S7CPubMed
TargetSolute carrier family 22 member 1(Homo sapiens (Human))
University Medicine Greifswald

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 2.23E+4nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3QSWPubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 315nMAssay Description:Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X87B8PubMedDrugBank
TargetMu-type opioid receptor(Homo sapiens (Human))
University of New Orleans

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataEC50:  9.40E+3nMAssay Description:Activity at human cloned mu opioid receptor assessed as reversal of DAMGO-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5N2WPubMedDrugBank
TargetDelta-type opioid receptor(Homo sapiens (Human))
F-59000 Lille

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X87B8PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 7.41E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ052WPubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
F-59000 Lille

Curated by ChEMBL
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)copy SMILEScopy InChI
Affinity DataIC50: 2.37E+3nMAssay Description:Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X87B8PubMedDrugBank