null

SMILES CN(C)C[C@@H]1C2CCC(CC2)[C@@H]1c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=JOQQHMGSIKNGAF-HLFYOVGASA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50026952   

TargetNorepinephrine transporter(RAT)
Lundbeck AIS

Curated by PDSP Ki Database
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataKi:  5.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1H2FPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Lilly Research Centre

Curated by ChEMBL
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataKi:  7.20nMAssay Description:In vitro inhibition of [3H]-NE re-uptake into synaptosomeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29W0DXFPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Lundbeck AIS

Curated by PDSP Ki Database
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataKi:  9.30nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1H2FPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Lilly Research Centre

Curated by ChEMBL
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataKi:  44nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29W0DXFPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Lundbeck AIS

Curated by PDSP Ki Database
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataKi:  51nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1H2FPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Lilly Research Centre

Curated by ChEMBL
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataKi:  57nMAssay Description:Displacement of [3H]-WIN-35,428 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29W0DXFPubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Lundbeck AIS

Curated by PDSP Ki Database
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataKi:  570nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1H2FPubMed
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1H2FPubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Lundbeck AIS

Curated by PDSP Ki Database
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1H2FPubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Lundbeck AIS

Curated by PDSP Ki Database
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1H2FPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Lundbeck AIS

Curated by PDSP Ki Database
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Effect on synaptosomal uptake inhibition of 5-hydroxytryptamine (5-HT)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MR6PubMed
TargetTransporter(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataIC50: 5.40nMAssay Description:Effect on synaptosomal uptake inhibition of Noradrenaline (NA)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MR6PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Lilly Research Centre

Curated by ChEMBL
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataIC50: 270nMAssay Description:In vitro ability of compound to inhibit 5-HT re-uptake of radiolabelled [3H]-tritium trasmitter into synaptosomeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29W0DXFPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Lilly Research Centre

Curated by ChEMBL
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:In vitro inhibition of [3H]-NE re-uptake into synaptosomeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29W0DXFPubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataIC50: 9.30nMAssay Description:Effect of compound on synaptosomal uptake inhibition of Dopamine (DA)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MR6PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Lilly Research Centre

Curated by ChEMBL
LigandPNGBDBM50026952((cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:In vitro inhibition of DA re-uptake into synaptosomeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29W0DXFPubMed