null

SMILES COc1cc(ccc1OCCCN1CCC(CC1)c1noc2cc(F)ccc12)C(C)=O

InChI Key InChIKey=XMXHEBAFVSFQEX-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 67 hits for monomerid = 50034043   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15ZCQPubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057DHPPubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Mayo Foundation for Medical Education and Research and Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  0.310nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057DHPPubMedDrugBank
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  0.350nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15ZCQPubMedDrugBank
TargetD(4) dopamine receptor(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15ZCQPubMedDrugBank
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Mayo Foundation for Medical Education and Research and Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057DHPPubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Hoechst Marion Roussel, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057DHPPubMedDrugBank
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  5.60nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMedDrugBank
TargetD(3) dopamine receptor(Homo sapiens (Human))
Hoechst Marion Roussel, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  7.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Mayo Foundation for Medical Education and Research and Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  12.3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057DHPPubMedDrugBank
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  13.3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMedDrugBank
TargetD(3) dopamine receptor(Homo sapiens (Human))
Hoechst Marion Roussel, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15ZCQPubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Mayo Foundation for Medical Education and Research and Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057DHPPubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Mayo Foundation for Medical Education and Research and Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057DHPPubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  16.2nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  21.4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMedDrugBank
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
Hoechst Marion Roussel, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  21.6nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  25nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMedDrugBank
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Mayo Foundation for Medical Education and Research and Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  33nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057DHPPubMed
Target5-hydroxytryptamine receptor 6(RAT)
Hoechst Marion Roussel, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  42.7nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Mayo Foundation for Medical Education and Research and Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  42.8nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Hoechst Marion Roussel, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  54nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMedDrugBank
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  112nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMedDrugBank
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  162nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Mayo Foundation for Medical Education and Research and Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  162nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Hoechst Marion Roussel, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  216nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMedDrugBank
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Hoechst Marion Roussel, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  319nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMed
TargetD(1A) dopamine receptor(RAT)
Hoechst Marion Roussel, Inc.

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  546nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6PR7PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  1.48E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  2.95E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  3.31E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  4.90E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  6.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057DHPPubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  8.32E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi:  9.33E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50034043(1-(4-{3-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperi...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5CHQPubMed
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