null
SMILES CN(C)C(=O)Oc1cccc(NC(=O)C2(CN)CCN(CC2)c2ncnc3[nH]cc(C)c23)c1
InChI Key InChIKey=PWPNYABQEOGNNC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 50044004
Affinity DataIC50: 32nMAssay Description:Inhibition of human LIMK1 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysis in presenc...More data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 69nMAssay Description:Inhibition of human Rock1 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysis in presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of human Rock2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysis in presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of human LIMK1 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysis in presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human Rock1 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysis in presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of human Rock2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysis in presenc...More data for this Ligand-Target Pair
Affinity DataKd: <1.00E+3nMAssay Description:Binding affinity to human LIMK2More data for this Ligand-Target Pair
Affinity DataKd: <1.00E+3nMAssay Description:Binding affinity to human Rock2More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Amakem Therapeutics N.V.
Curated by ChEMBL
Amakem Therapeutics N.V.
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PKA (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amakem Therapeutics N.V.
Curated by ChEMBL
Amakem Therapeutics N.V.
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of LIMK1 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of LIMK2 (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar
In DepthDetails
In DepthDetails
In DepthDetails
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...More data for this Ligand-Target Pair