null
SMILES COc1cccc2[C@H](CN(C)CCc3ccc4ccoc4c3)CCCc12
InChI Key InChIKey=MHPMXTGKTXJIDI-IBGZPJMESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 50057128
Affinity DataKi: 2nMAssay Description:Inhibition constant against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]-rauwolscineMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: 2.40nMAssay Description:In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]-rauwolscineMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Inhibition of [3H]- rauwolscine binding to human alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.77nMAssay Description:Evaluated for affinity at 5-HT uptake site using [3H]paroxetine as radioligand in radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:In vitro binding affinity towards rat serotonin transporterMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of [3H]- paroxetine binding to 5-HTT receptor, serotonin transporterMore data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Inhibition of [3H]- rauwolscine binding to alpha-2B adrenergic receptorMore data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]-rauwolscineMore data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Compound was evaluated for its binding affinity to Dopamine receptor D2 in rat brain using [3H]- spiroperidol radioligand assayMore data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Inhibition constant against Dopamine receptor D2 in olfactory bulbectomized ratMore data for this Ligand-Target Pair
Affinity DataKi: 144nMAssay Description:Inhibition constant against 5-Hydroxytryptamine 2 receptor in olfactory bulbectomized ratMore data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: 234nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D4More data for this Ligand-Target Pair
Affinity DataKi: 744nMAssay Description:Compound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assayMore data for this Ligand-Target Pair
Affinity DataKi: 836nMAssay Description:Compound was evaluated for its binding affinity to beta-1 receptor in rat brain using [3H]- DHA radioligand assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [125I]- R91150 binding to 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
TargetTransporter(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [3H]-nisoxetine binding to Norepinephrine transporter from rat cortexMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [3H]- mesulergine binding to 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [3H]pyrilamine binding to Histamine H1 receptorMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [3H]WIN-35428 binding to Dopamine transporter of rat striatumMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [3H]spiperone binding to Dopamine receptor D2More data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [3H]- prazosin binding to alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.74E+3nMAssay Description:Compound was evaluated for its binding affinity to beta-2 receptor in rat brain using [3H]- DHA radioligand assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 13.1nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration against serotonin transporterMore data for this Ligand-Target Pair