null

SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O

InChI Key InChIKey=ZIXDDEATQSBHHL-BEFAXECRSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50067584   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Saccharomyces cerevisiae (Baker's yeast))
Centre de Recherche de Gif

LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 0.780nMpH: 7.5Assay Description:Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2319TSJPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human recombinant FTase using [3H]farnesyldiphosphateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HD7ZN5PubMed
TargetProtein farnesyltransferase alpha subunit/subunit beta(Trypanosoma brucei brucei)
Centre de Recherche de Gif

LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2319TSJPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibitory activity of the compound was evaluated against farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X34WNTPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 0.510nMAssay Description:Inhibitory activity against farnesyltransferase (FT) using SPA assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73CWQPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of mammalian FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26W99CHPubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 0.610nMAssay Description:Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22F7MQ7PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of [3H]-FPP incorporation into Ha-ras protein by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QF8S6VPubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of mammalian protein farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TQ60Z4PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Trypanosoma brucei protein farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TQ60Z4PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2XFPPubMed
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibition of farnesyltransferase from bovine brainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3KTCPubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX9CVXPubMed
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mammalian H-Ras processing in NIH 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26W99CHPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FTase isolated from human Burkitt's lymphoma cells assessed as decrease in transfer of [3H]farnesyl from [3H]farnesyl PPi to H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542R5NPubMed
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of human GGTase1 in human Burkitt lymphoma (Daudi) cell supernatant using [3H]geranylgeranylMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HD7ZN5PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50067584((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2319TSJPubMed