null

SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)[C@H](CSc1ccccc1)C(=O)NO

InChI Key InChIKey=UBFGIEDUTRCMEQ-FSSWDIPSSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50069608   

TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069608((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Tested for inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cells ( a human B-cell line); value ranges from 40-8...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TT4Q3WPubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Centre de Recherches

Curated by ChEMBL
LigandPNGBDBM50069608((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of TNF(tumor necrosis factor) in human bloodMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HM57NSPubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Centre de Recherches

Curated by ChEMBL
LigandPNGBDBM50069608((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibitory activity against Tumor necrosis factor alpha-converting enzyme (TACE) in blood.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HM57NSPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069608((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibitory activity of the compound towards human recombinant fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TT4Q3WPubMed