null

SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(O)=O)-c1ncco1)OC1CCOCC1

InChI Key InChIKey=ZZWWXIBKLBMSCS-FQEVSTJZSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50069756   

TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:In vitro inhibition of human recombinant His-tagged ACC2 assessed as malonyl-CoA levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2X6JPubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:In vitro inhibition of human recombinant His-tagged ACC1 assessed as malonyl-CoA levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DR2X6JPubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of ACC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5JXGPubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ACC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5JXGPubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)copy SMILEScopy InChI
Affinity DataIC50: 3.56nMAssay Description:4.5 μL of 2.2×ACC2 enzyme (1.1 nM) working solution was added to a 384-well plate; and then 0.5 μL of different concentrations of compound ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25H7KFVUS Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2028VPNUS Patent
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2028VPNUS Patent
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2028VPNUS Patent
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:4.5 μL of 2.2×ACC1 enzyme (2 nM) working solution was added to a 384-well plate; and then 0.5 μL of different concentrations of compound we...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25H7KFVUS Patent
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50069756(CHEMBL3407547 | Firsocostat | ND-630 | NDI-010976 ...)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:Inhibition of recombinant human C-terminal His-tagged ACC1 (1 to 2383 residues) expressed in baculovirus infected Sf9 insect cells preincubated for 1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GX4G85PubMed