null

SMILES CN([C@@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(CC1)c1ccccc1)S(=O)(=O)c1cccc2cnccc12

InChI Key InChIKey=RJVLFQBBRSMWHX-DHUJRADRSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50087267   

TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 158nMpH: 7.4Assay Description:hP2X7-expressing HEK 293 cells were re-suspended at 2.5 × 10^6 cells/mL in assay buffer composed of 10 mM HEPES, 5 mM N-methyl-D-glutamine, 5.6 mM KC...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833QRTPubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Homo sapiens (Human))
National Taiwan Normal University

Curated by ChEMBL
LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of human CaMKIIalpha using calmodulin and syntide-2 incubated for 15 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2280C0JPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration of the compound was evaluated against P2X purinoceptor 7More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26M3626PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Antagonistic activity against P2X7 receptor measured as the ATP dependent calcium influx in human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4W57PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 175nMAssay Description:Antagonist activity at human purinergic P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61K0PPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulation at 10 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XS5VF0PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Antagonist activity at P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced pore formationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22N52B0PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced fluorescent ethidium accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23T9H3SPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataEC50:  34nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VX0H71PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human P2X7 receptor in human THP1 cells assessed as inhibition of BzATP-induced IL8 release pretreated for 30 mins before bzAT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0NB3PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced intracellular ethidium bromi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H133QDPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H133QDPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 143nMAssay Description:Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H133QDPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 143nMAssay Description:Antagonist activity at P2X7 receptor in LPS/IFN-gamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preinc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H133QDPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of rat P2X7 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22N5427PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human P2X7 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22N5427PubMed
TargetP2X purinoceptor(Cavia porcellus)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of guinea pig P2X7 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22N5427PubMed
Targetp2X7 purinoceptor(Canis lupus familiaris)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of dog P2X7 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22N5427PubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataEC50:  1.00E+5nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VX0H71PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Antagonist activity at recombinant human P2X7 receptor assessed as inhibition of BzATP-mediated Yo-Pro uptake measured for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61MQHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced accumulation of ethidium+ after 120 mins...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61MQHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 12.6nMAssay Description:Antagonist activity at P2X7 receptor in human lymphocytes assessed as inhibition of ATP-induced Ba2+ influxMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KDRPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 50.1nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium influxMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2251KDRPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptake after 2 hrs by f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0NB3PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 9.60E+4nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium bromide uptake after 2 hrs by f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5X8KPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Antagonist activity at human P2X7 receptor in expressed in HEK293 cells assessed as inhibition of BzATP-induced EtBr uptakeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75JWBPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Antagonist activity at P2X7 in LPS/IFN gamma differentiated human THP-1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75JWBPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced EtBr uptake after 2 hrs by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75JWBPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced ethidium ion uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RR227RPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 129nMAssay Description:Antagonist activity at P2X7 receptor expressed in LPS/IFNgamma-differentiated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta produ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RR227RPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Antagonist activity at P2X7 receptor in human lymphocytes assessed as inhibition of ATP-induced ethidium ion uptake preincubated for 5 mins followed ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RR227RPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 94nMAssay Description:Antagonist activity at P2X7 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M0BX7PubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Gwangju Institute of Science and Technology

LigandPNGBDBM50087267((1-(N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L-t...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Antagonistic activity against P2X7 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2J966XJPubMed