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SMILES N[C@@]1([C@H]2[C@@H](C[C@@H]1F)[C@@H]2C(O)=O)C(O)=O

InChI Key InChIKey=DIWVNJFXRKZAGI-FJNNMDBYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50094841   

TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataKi:  47.7nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 2 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataKi:  65.9nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  45.4nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  29.4nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated in presence of 30 microM glutamic acidMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  2.64E+3nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  153nMAssay Description:Agonist activity at human mGlu2 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  76nMAssay Description:Agonist activity at human mGlu3 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  154nMAssay Description:Agonist activity at rat mGlu2 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  97nMAssay Description:Agonist activity at rat mGlu3 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu2 receptor expressed in CHO cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu3 receptor expressed in CHO cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGlu4 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGlu1 receptor expressed in CHO cell membranes by intracellular Ca2+ assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGlu6 receptor expressed in HEK293T cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human mGlu8 receptor expressed in CHO cell membranes by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu1 receptor expressed in CHO cell membranes in presence of glutamate by intracellular Ca2+ assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu4 receptor expressed in CHO cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu6 receptor expressed in HEK293T cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))TBA
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human mGlu8 receptor expressed in CHO cell membranes in presence of glutamate by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5Z03PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50:  29.4nMAssay Description:Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094841((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against Metabotropic glutamate receptor 3 expressed in CHO cells was evaluated in presence of 30 microM glutamic acidMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24J0DC8PubMed