null

SMILES CC(C)C(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=HUQRFIVGTWYKFR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50100520   

TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis, LLC

US Patent
LigandPNGBDBM50100520(CHEMBL3327077 | US10377744, Compound No. 2422 | US...)copy SMILEScopy InChI
Affinity DataKi:  0.310nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N3009KUS Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis, LLC

US Patent
LigandPNGBDBM50100520(CHEMBL3327077 | US10377744, Compound No. 2422 | US...)copy SMILEScopy InChI
Affinity DataKi:  0.310nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Q81H7MUS Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis, LLC

US Patent
LigandPNGBDBM50100520(CHEMBL3327077 | US10377744, Compound No. 2422 | US...)copy SMILEScopy InChI
Affinity DataKi:  0.310nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2JJQPubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis, LLC

US Patent
LigandPNGBDBM50100520(CHEMBL3327077 | US10377744, Compound No. 2422 | US...)copy SMILEScopy InChI
Affinity DataKi:  0.660nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Q81H7MUS Patent
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM50100520(CHEMBL3327077 | US10377744, Compound No. 2422 | US...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of rat soluble epoxide hydrolase using [3H]-t-DPPO as a substrate by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2JJQPubMed