null

SMILES ONC(=O)[C@H]1CCCOC(=O)NCCCC[C@H](NC(=O)[C@@H]1Cc1ccc(cc1)-c1ccccc1C(F)(F)F)C(=O)NCC(=O)N1CCOCC1

InChI Key InChIKey=RWKJBOMUESGCBO-REUBFRLUSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50104975   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  2.80nMAssay Description:Inhibition of porcine TNF-alpha converting enzyme(pTACE).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  2.80nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  2.80nMAssay Description:Inhibition of porcine TACEMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T72GV7PubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  126nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  200nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetCollagenase 3(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  653nMAssay Description:Inhibition of matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
TargetCollagenase 3(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  653nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetMatrilysin(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  834nMAssay Description:Inhibition of matrix metalloprotease-7More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
TargetMatrilysin(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  834nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetMatrix metalloproteinase-16(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of matrix metalloprotease-16More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-1(MMP-1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T72GV7PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-2(MMP-2)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T72GV7PubMed
TargetMatrix metalloproteinase-15(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MMP15More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetStromelysin-2(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MMP10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetMatrix metalloproteinase-16(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MMP16More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetStromelysin-1(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetStromelysin-1(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
TargetMatrix metalloproteinase-15(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of matrix metalloprotease-15More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
TargetStromelysin-2(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of matrix metalloprotease-10More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of human matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
DuPont Pharmaceuticals Company

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4WM2PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-9(MMP-9)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T72GV7PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
University of Athens

Curated by ChEMBL
LigandPNGBDBM50104975((8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-bip...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of matrix metalloprotease-14More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD6XRTPubMed