null

SMILES Oc1c(Cl)c(N=CCN2CCOCC2)c(O)c2ncccc12

InChI Key InChIKey=DWRQCWWWWDTWHB-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50106497   

TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataKi:  29nMAssay Description:Inhibition of human Cdc25AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8SHKPubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataKi:  89nMAssay Description:Inhibition of human Cdc25CMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8SHKPubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataKi:  95nMAssay Description:Inhibition of human Cdc25BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8SHKPubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352) assessed as incorporation of [3H]-methyl group from [3H-Me]-SAM to biotinylated H4K20 p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7BS2PubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:Inhibitory activity against recombinant CDC25CMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T1535SPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory Activity against Recombinant Human PTP1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X34WR5PubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataEC50: <5.00E+3nMAssay Description:Inhibition of SETD8 in HEK293T cells assessed as reduction in H4K20me level after 2 to 3 days by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1P3ZPubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory Activity against Recombinant Human VHRMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X34WR5PubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of recombinant human Cdc25A using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6TS1PubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant human Cdc25C using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6TS1PubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of recombinant human Cdc25B using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6TS1PubMed
TargetN-lysine methyltransferase KMT5A(Homo sapiens (Human))
Icahn School of Medicine at Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of N-terminal His6-tagged human SETD8 (191 to 352 residues) expressed in Escherichia coli Rosseta-2(DE3) cells using histone peptide subst...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1P3ZPubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibitory activity against recombinant human cell division cycle 25BMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X34WR5PubMed