null

SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC

InChI Key InChIKey=ORRFUYVNMZSYIC-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50118826   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibitory concentration against platelet-derived growth factor receptor beta phosphorylation in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2668CKRPubMed
TargetDual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 6More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of PDGF receptor alpha autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 1.49E+4nMAssay Description:Inhibition of Flt3 autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of c-Jun N-terminal kinase (Jnk)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Mitogen activated protein kinase kinase 1More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Colony stimulating factor 1 receptor (CSF-1R) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibition of Mast/stem cell growth factor receptor (c-kit) autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JH3MXFPubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50118826(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X929PJPubMed