null

SMILES CCn1c(cc2c1nc(Nc1nccs1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1

InChI Key InChIKey=IICNZQXMUDVBGZ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50121379   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb Research& Development

Curated by ChEMBL
LigandPNGBDBM50121379(CHEMBL3622134)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of JAK2 (unknown origin) using 5-FAMKKKKEEIYFFFG-OH as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q2421MPubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Bristol-Myers Squibb Research& Development

Curated by ChEMBL
LigandPNGBDBM50121379(CHEMBL3622134)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant Tyk2 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q2421MPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol-Myers Squibb Research& Development

Curated by ChEMBL
LigandPNGBDBM50121379(CHEMBL3622134)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of JAK2 in human SET2 cells assessed as inhibition of cell proliferation after 72 hrs by [3H]-thymidine incorporation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q2421MPubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research& Development

Curated by ChEMBL
LigandPNGBDBM50121379(CHEMBL3622134)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q2421MPubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research& Development

Curated by ChEMBL
LigandPNGBDBM50121379(CHEMBL3622134)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using fluoresceinated peptide as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q2421MPubMed