null

SMILES CN(C)c1cccc(c1)C(=O)Nc1ccc(C)c(NC(=O)c2ccc(O)cc2)c1

InChI Key InChIKey=PYEFPDQFAZNXLI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50153835   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8K57PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of protein kinase c-rafMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8K57PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC10WVPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of c-Raf in the presence of 100uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27082B4PubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of B-Raf in the presence of 100uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27082B4PubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 570nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27082B4PubMed
TargetHeat shock factor protein 1(Homo sapiens (Human))
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5J9DPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SAPK2a/p38-alphaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB82RHPubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SAPK2b/p38betaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB82RHPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of cRAF1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB82RHPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of Raf1 kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X29S8PubMed
TargetHeat shock factor protein 1(Homo sapiens (Human))
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 17-AAG-induced HSF1 pathway in human SKOV3 cells assessed as reduction in HSP72 induction preincubated for 1 hr followed by 17-AAG addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5J9DPubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50153835(1-(3-dimethylaminophenylcarboxamido)-3-(4-hydroxyp...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of RIP2 in the presence of 100uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27082B4PubMed