null

SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Br)n1)NC(=O)[C@@H]1CCC(=O)N1

InChI Key InChIKey=MCTSLSUHNRJPGD-BZSNNMDCSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50158392   

TargetThyrotropin-releasing hormone receptor(MOUSE)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158392(CHEMBL3781024)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8NKFPubMed
TargetThyrotropin-releasing hormone receptor(Mus musculus)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158392(CHEMBL3781024)copy SMILEScopy InChI
Affinity DataEC50: >5.00E+4nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8NKFPubMed
TargetThyrotropin-releasing hormone receptor(Mus musculus)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158392(CHEMBL3781024)copy SMILEScopy InChI
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8NKFPubMed
TargetThyrotropin-releasing hormone receptor(Mus musculus)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158392(CHEMBL3781024)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8NKFPubMed
TargetThyrotropin-releasing hormone receptor(MOUSE)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158392(CHEMBL3781024)copy SMILEScopy InChI
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8NKFPubMed
TargetThyrotropin-releasing hormone receptor(MOUSE)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50158392(CHEMBL3781024)copy SMILEScopy InChI
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8NKFPubMed