null
SMILES COC(=O)[C@@H]1C[C@H](OC(C)=O)C(=O)[C@H]2[C@@]1(C)CC[C@H]1C(=O)O[C@@H](C[C@]21C)c1ccoc1
InChI Key InChIKey=OBSYBRPAKCASQB-AGQYDFLVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 187 hits for monomerid = 50159165
TargetKappa-type opioid receptor [D138N](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 0.590nM ΔG°: -12.6kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
Affinity DataKi: 0.75nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.75nMAssay Description:Displacement of [3H]U69,593 from rat cloned KORMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells by visible spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of [3H]diprenorphine binding to human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]diprenorphine binding from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of [3H]diprenorphine binding to human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Binding affinity to kappa opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Inhibition of [125I]- IOXY binding to human Opioid receptor kappa1More data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Displacement of [125]OXY from kappa opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]diprenorphine from human KOPR expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor (unknown origin) expressed in HEK293T cells after 1.5 hrs by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Displacement of [3H]diprenorphine from human KOPR expressed in CHO cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor [D138A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 3.5nM ΔG°: -11.5kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [I294A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 3.90nM ΔG°: -11.5kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of [3H]-U-69,593 binding to rat opioid receptor kappa 1 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Case Western Reserve University
Curated by PDSP Ki Database
Case Western Reserve University
Curated by PDSP Ki Database
TargetKappa-type opioid receptor [K227A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 4.40nM ΔG°: -11.4kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
Affinity DataKi: 6.20nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [M226A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 7.20nM ΔG°: -11.1kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [E297A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 7.20nM ΔG°: -11.1kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
Affinity DataKi: 7.40nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptorMore data for this Ligand-Target Pair
Affinity DataKi: 7.40nMAssay Description:Displacement of [3H]U69593 from human recombinant kappa opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor [H291F](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 7.80nM ΔG°: -11.1kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [I135A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 8.30nM ΔG°: -11.0kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [K212A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 8.30nM ΔG°: -11.0kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [K200A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 9.30nM ΔG°: -10.9kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
Affinity DataKi: 10nM ΔG°: -10.9kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
Affinity DataKi: 17.5nMAssay Description:Displacement of [3H]diprenorphine from rat kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor [Y312F](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 19nM ΔG°: -10.5kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [Y139F](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 19nM ΔG°: -10.5kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [H291A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 19nM ΔG°: -10.5kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [Y312A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 20nM ΔG°: -10.5kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [Y119F](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 25nM ΔG°: -10.4kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [Y139A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 26nM ΔG°: -10.3kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [Y66A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 27nM ΔG°: -10.3kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [Y313F](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 31nM ΔG°: -10.2kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [M142A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 58nM ΔG°: -9.87kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [Y320F](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 80nM ΔG°: -9.67kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [Y320A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 150nM ΔG°: -9.30kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [Y119A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 260nM ΔG°: -8.98kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor [Q115A](Homo sapiens (Human))
University of North Carolina School of Medicine
University of North Carolina School of Medicine
Affinity DataKi: 590nM ΔG°: -8.49kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]diprenorphine from mouse delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair