null

SMILES Cc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(cc12)-c1ccc(c(F)c1)-c1ccccc1

InChI Key InChIKey=WNFJTGITKNIPNM-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50168761   

TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration against human prostaglandin E2 synthase (mPGES-1)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition against recombinant human mPGES-2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition against human Thromboxane synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro binding affinity against FLAP (5-Lipoxygenase activation protein)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q1XPubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of TX synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6C0KPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant mPGES-1 using PGH2 as substrate incubated 20 mins prior to substrate addition measured after 30 secs by EIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z3210HPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FLAPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6C0KPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of mPGES1 in IL-1beta treated human A549 cell microsomal membrane assessed as residual enzyme activity after 1 min by measuring PGE2 level...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C6XGXPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X292VPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mPGES2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6C0KPubMed