null

SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl

InChI Key InChIKey=DCOPUUMXTXDBNB-UHFFFAOYSA-M

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50174201   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QR4VPJPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataKi:  10nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18X97PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JT4PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataKi:  38nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JT4PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataKi:  50nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QR4VPJPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataKi:  50nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2S18110PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataKi:  75nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JT4PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QR4VPJPubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2S18110PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataKi:  260nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18X97PubMed
TargetDipeptidyl peptidase 3(Bos mutus)TBA
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataKi:  3.00E+5nMAssay Description:Competitive inhibition of Capra hircus (goat) brain DPP-3 using Arg-Arg-4mbetaNA as substrate assessed as liberation of 4mbetaNA from substrate prein...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60RZ1
TargetSerum paraoxonase/arylesterase 1(Homo sapiens (Human))
Atatürk University

LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataKi:  8.05E+5nM ΔG°:  -4.22kcal/mole IC50: 1.64E+6nMpH: 10.5 T: 2°CAssay Description:The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PKRPubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
King Saud University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of ovine COX2-mediated prostaglandin alpha production by enzyme immuno assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1PHNPubMed
TargetDipeptidyl peptidase 3(Bos mutus)TBA
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of Capra hircus (goat) brain DPP-3 using Arg-Arg-4mbetaNA as substrate assessed as liberation of 4mbetaNA from substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z60RZ1
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant COX2 catalytic activity using arachidonic acid as substrate pre-incubated for 10 mins followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48FJPubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of ovine COX1 catalytic activity using arachidonic acid as substrate pre-incubated for 10 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48FJPubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QJ7MVZPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 840nMAssay Description:Inhibition of human recombinant COX2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QJ7MVZPubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of ovine COX1 by colorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057KNJPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant COX2 by colorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057KNJPubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition by colorimetric anal...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4H26PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 840nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition by color...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4H26PubMed
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 3.63E+5nMAssay Description:CLC-2 activity using cell-free assays, e.g., binding assays; with purified enzymes.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HX1GVZUS Patent
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:Inhibition of ovine COX1-mediated prostaglandin alpha production by enzyme immuno assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SJ1PHNPubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03C1F
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 840nMAssay Description:Inhibition of human recombinant COX-2 by EIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2988B9CPubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of ovine COX-1 by EIA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2988B9CPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Dallas Department of Veterans Affairs Medical Center

Curated by PDSP Ki Database
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha production using arachidonic acid as substrate by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX7D4CPubMed
TargetAlbumin(Bos taurus)TBA
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 19nMMore data for this Ligand-Target Pair
In DepthDetails
TargetProstaglandin G/H synthase 1/2(Bos taurus)
Ciba-Geigy Limited

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+9nMAssay Description:In vitro inhibition of bovine prostaglandin G/H synthase, using bovine seminal vesicle microsomal preparations; IC50 in umol/LMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2251MD5PubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
King Saud University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6DWZPubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6DWZPubMed
TargetAldo-keto reductase family 1 member C3(Homo sapiens (Human))
University of Ljubljana

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of recombinant human AKR1C3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2VX4PubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of ovine COX1 assessed as PGF2alpha production from PGH2 after 5 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29ZTPubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
King Saud University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of ovine COX2 assessed as PGF2alpha production from PGH2 after 5 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29ZTPubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Alexandria University

Curated by ChEMBL
LigandPNGBDBM50174201(ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGF2alpha production using arachidonic acid as substrate by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX7D4CPubMed