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SMILES Oc1c(oc2ccccc2c1=O)-c1ccccc1

InChI Key InChIKey=HVQAJTFOCKOKIN-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50187668   

TargetPyruvate kinase PKM(Homo sapiens (Human))TBA
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataKi:  3.53E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£ degli Studi di Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataKi:  5.10E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 1 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1045TPubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£ degli Studi di Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataKi:  5.21E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1045TPubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataKi:  5.54E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1045TPubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataKi:  5.63E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 9 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1045TPubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataKi:  6.59E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1045TPubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataKi:  6.65E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1045TPubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 2 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1045TPubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Cagliari

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataKi:  9.30E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1045TPubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C6Z93PubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))TBA
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 1.75E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetDipeptidyl peptidase 3(Homo sapiens (Human))
Josip Juraj Strossmayer University of Osijek

LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 1.88E+5nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of flavonoids toward human DPP III was assayed in a 50 mM Tris-HCl buffer, pH 7.4. In brief, recombinant human DPP III (0.29 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X34WBSPubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))TBA
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 2.09E+6nMAssay Description:In vitro antibacterial activity was determined as inhibitory concentration causing 50% DNA-gyrase supercoiling inhibition (SCI)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FX7CM7
TargetCytochrome P450 1B1(Homo sapiens (Human))
Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec - Research Center, Québec, Québec, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval,

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH P450 reductase using 7-ethoxyresorufin as substrate in pre...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q20QWPubMed
TargetAurora kinase B(Homo sapiens (Human))
Konkuk University

LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 4.29E+3nMAssay Description:The kinase assay was performed using the EMD Millipore KinaseProfiler service assay protocol. Aurora B kinase was supplied by EMD Millipore Corp. The...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M61J08PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Chosun University

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to ABCB1 nucleotide binding domain 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2J3WPubMed
TargetFatty acid synthase(Homo sapiens (Human))
Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of FASMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3NB7PubMed
TargetCalmodulin-1(Human)
Universidad Aut£noma del Estado de Morelos

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 5.52E+4nMAssay Description:Inhibition of human recombinant calmodulin assessed as inhibition of calmodulin-sensitive cAMP phosphodiesterase activation after 15 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0NM0PubMed
TargetAndrogen receptor(Homo sapiens (Human))
Meijo University

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 2.35E+4nMAssay Description:Antagonist activity at androgen receptor in human MDA-kb2 cells assessed as inhibition of DHT-induced luciferase activity by luciferase reporter gene...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0MNQPubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
Universidad de Santiago de Chile

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 15-hLO2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37KNPubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Universidad de Santiago de Chile

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 12-hLOMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37KNPubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Universidad de Santiago de Chile

Curated by ChEMBL
LigandPNGBDBM50187668(3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibition of 15-hLO1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37KNPubMed