null

SMILES CC(C)N1c2ccccc2CC[C@@H](NC(=O)[C@@H](Cc2ccccc2OC(F)(F)F)NC(=O)OC(C)(C)C)C1=O

InChI Key InChIKey=JDORNNHHHQXMCA-NHCUHLMSSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50216671   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(CHEMBL247828 | tert-butyl (R)-1-((R)-1-isopropyl-2...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Binding affinity at human inactive state Nav1.7 by whole cell electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CCFPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(CHEMBL247828 | tert-butyl (R)-1-((R)-1-isopropyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human sodium channel Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B00PubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(CHEMBL247828 | tert-butyl (R)-1-((R)-1-isopropyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human NaV1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W098VMPubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(CHEMBL247828 | tert-butyl (R)-1-((R)-1-isopropyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+3nMAssay Description:Displacement of [3H]diltiazem from human Cav1.2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CCFPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(CHEMBL247828 | tert-butyl (R)-1-((R)-1-isopropyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6J4TPubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(CHEMBL247828 | tert-butyl (R)-1-((R)-1-isopropyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CCFPubMed