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SMILES CC(C)C[C@H](N)C(O)=O

InChI Key InChIKey=ROHFNLRQFUQHCH-YFKPBYRVSA-N

PDB links: 84 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50219348   

TargetProton-coupled amino acid transporter 1(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM50219348((2S)-2-amino-4-methylpentanoic acid | (S)-(+)-leuc...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+8nMAssay Description:Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ882DPubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Homo sapiens (Human))
Human BioMolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50219348((2S)-2-amino-4-methylpentanoic acid | (S)-(+)-leuc...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of TNAP by analogous luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6JHRPubMed
LigandPNGBDBM50219348((2S)-2-amino-4-methylpentanoic acid | (S)-(+)-leuc...)copy SMILEScopy InChI
Affinity DataIC50: 8.70E+4nMAssay Description:Inhibition of human LAT1 expressed in HEK293-T-Rex cells assessed as inhibition of [3H]-gabapentin uptake by scintillation counting cis-inhibition as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22F7S4PPubMed
LigandPNGBDBM50219348((2S)-2-amino-4-methylpentanoic acid | (S)-(+)-leuc...)copy SMILEScopy InChI
Affinity DataIC50: 8.50E+4nMAssay Description:Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8J66PubMed
TargetPhospholipase A-2-activating protein(Homo sapiens (Human))
Human BioMolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50219348((2S)-2-amino-4-methylpentanoic acid | (S)-(+)-leuc...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of PLAP by analogous luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6JHRPubMed
TargetIntestinal-type alkaline phosphatase(Homo sapiens (Human))
Human BioMolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50219348((2S)-2-amino-4-methylpentanoic acid | (S)-(+)-leuc...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of IAP by analogous luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6JHRPubMed