null
SMILES [H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccccc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H]
InChI Key InChIKey=QMGVPVSNSZLJIA-FVWCLLPLSA-N
PDB links: 11 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 50225707
Affinity DataKi: 5nMAssay Description:Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranes preincubated for 30 mins followed by [3...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 12nMAssay Description:Displacement of [3H]strychnine from glycine receptor alpha 1 in rat brain synaptic membranesMore data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Displacement of [3H]strychnine from recombinant human glycine receptor alpha 1 expressed in HEK293 cell membranes after 30 mins by liquid scintillati...More data for this Ligand-Target Pair
Affinity DataKi: 123nMAssay Description:Displacement of [3H]strychnine from human glycine receptor subunit alpha-1 expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 93nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 expressed in human tsA201 cells assessed as inhibition of glycine-induced receptor ...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
The German University in Cairo
Curated by ChEMBL
The German University in Cairo
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced rece...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 expressed in human tsA201 cells assessed as reduction in glycine-induced response by fl...More data for this Ligand-Target Pair
Affinity DataIC50: 151nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 expressed in human tsA201 cells assessed as reduction in glycine-induced response by fl...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
The German University in Cairo
Curated by ChEMBL
The German University in Cairo
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1beta expressed in HEK293 cells assessed as reduction in glycine-induced whole cell curre...More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 assessed as inhibition of glycine-induced current measured at the later state of compou...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
The German University in Cairo
Curated by ChEMBL
The German University in Cairo
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1beta expressed in human tsA201 cells assessed as reduction in glycine-induced response b...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
The German University in Cairo
Curated by ChEMBL
The German University in Cairo
Curated by ChEMBL
Affinity DataIC50: 513nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1beta expressed in human tsA201 cells assessed as reduction in glycine-induced response b...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 expressed in human tsA201 cells assessed as reduction in glycine-induced response incub...More data for this Ligand-Target Pair
Affinity DataIC50: 151nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 expressed in human tsA201 cells assessed as reduction in glycine-induced response incub...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
The German University in Cairo
Curated by ChEMBL
The German University in Cairo
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1beta expressed in human tsA201 cells assessed as reduction in glycine-induced response i...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
The German University in Cairo
Curated by ChEMBL
The German University in Cairo
Curated by ChEMBL
Affinity DataIC50: 513nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1beta expressed in human tsA201 cells assessed as reduction in glycine-induced response i...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 expressed in HEK293 cells assessed as reduction in glycine-induced currents by whole-ce...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
The German University in Cairo
Curated by ChEMBL
The German University in Cairo
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1beta expressed in HEK293 cells assessed as reduction in glycine-induced currents by whol...More data for this Ligand-Target Pair
Affinity DataIC50: 134nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 assessed as inhibition of glycine-induced current measured at the onset of compound app...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
The German University in Cairo
Curated by ChEMBL
The German University in Cairo
Curated by ChEMBL
Affinity DataIC50: 58nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in HEK293 cells assessed as inhibition of glycine-induced current at...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1/beta(Homo sapiens (Human))
The German University in Cairo
Curated by ChEMBL
The German University in Cairo
Curated by ChEMBL
Affinity DataIC50: 182nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 beta expressed in human tsA201 cells assessed as inhibition of glycine-induced rece...More data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Antagonist activity at recombinant human glycine receptor alpha 1 expressed in HEK293 cells assessed as inhibition of glycine-induced current at -50 ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Antagonist activity at human glycine receptor subunit alpha-1 expressed in HEK293 cells assessed as reduction in glycine-induced whole cell currents ...More data for this Ligand-Target Pair