null
SMILES CN([C@@H]1C[C@H](CS(=O)(=O)N2CCCC2)C1)c1ncnc2[nH]ccc12
InChI Key InChIKey=JMQCMAJMXFBXRL-BETUJISGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50243843
Affinity DataIC50: 21nMAssay Description:In vitro inhibitory activity against human AchE (Acetylcholinesterase)More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:The ability to inhibit [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor in rat brain corticesMore data for this Ligand-Target Pair
Affinity DataIC50: 244nMAssay Description:Inhibition of recombinant human JAK2 using FITC-KGGEEEEYFELVKK as substrate in presence of 1 mM ATP by mobility shift assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer Inc.
Curated by ChEMBL
Pfizer Inc.
Curated by ChEMBL
Affinity DataIC50: 211nMAssay Description:Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha induced STAT3 phosphorylation preincubated for 45 mins followed by IFN...More data for this Ligand-Target Pair
Affinity DataIC50: 1.97E+3nMAssay Description:Inhibition of JAK2 in CD34+ human whole blood assessed as reduction in EOP induced STAT5 phosphorylation preincubated for 45 mins followed by EOP add...More data for this Ligand-Target Pair