null

SMILES CN(C(=O)CN1CCN(C)CC1)c1ccc(N\C(=C2/C(=O)Nc3cc(ccc23)C(O)=O)c2ccccc2)cc1

InChI Key InChIKey=KEHNCEDHZGQSNP-DQSJHHFOSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248924   

TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University of Texas at Austin

Curated by ChEMBL
LigandPNGBDBM50248924(CHEMBL4099431 | US10981896, Compound 20)copy SMILEScopy InChI
Affinity DataKi:  149nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833VFFPubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University of Texas at Austin

Curated by ChEMBL
LigandPNGBDBM50248924(CHEMBL4099431 | US10981896, Compound 20)copy SMILEScopy InChI
Affinity DataIC50: 1.15E+3nMAssay Description:The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24X5BWVUS Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University of Texas at Austin

Curated by ChEMBL
LigandPNGBDBM50248924(CHEMBL4099431 | US10981896, Compound 20)copy SMILEScopy InChI
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2833VFFPubMed