null
SMILES NC1=NC(=O)\C(N1)=C1/CCNC(=O)c2[nH]c(Br)cc12
InChI Key InChIKey=ATBAETXFFCOZOY-DAXSKMNVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 26 hits for monomerid = 50259155
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)
Curated by ChEMBL
Jamia Hamdard (Hamdard University)
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Antagonist activity in phenoxybenzamine-treated rat by Pressor assayMore data for this Ligand-Target Pair
In DepthDetails
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)
Curated by ChEMBL
Jamia Hamdard (Hamdard University)
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of GSK3beta (unknown origin) expressed in Sf9 cells using GS1 as substrate and [gamma32]ATP after 30 min by scinitllation countingMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
TargetGlycogen synthase kinase 3(Plasmodium falciparum (isolate 3D7))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Antagonist effect against 2-methyl-5-HT activity at 5-HT3 receptor in longitudinal muscle myenteric plexus from guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 40nMAssay Description:Activity at human B2 receptor transfected in CHO cells assessed as ability to antagonize BK-induced inositol-phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 70nMAssay Description:Activity at human B2 receptor transfected in CHO cells assessed as ability to antagonize BK-induced inositol-phosphate accumulationMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 100nMAssay Description:Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cellsMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 470nMAssay Description:Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cellsMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 6nMAssay Description:Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 500nMAssay Description:Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cellsMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 35nMAssay Description:Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cellsMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 7.00E+3nMAssay Description:Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cellsMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 600nMAssay Description:Antagonist potency on BK-induced contraction of guinea pig ileum longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 25nMAssay Description:Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cellsMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 700nMAssay Description:Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced responseMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 1.95E+3nMAssay Description:Antagonist activity against adrenergic alpha-1A receptor in rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractionMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 42nMAssay Description:Antagonist activity in rat uterus by uterotonic assayMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity in phenoxybenzamine-treated rat by Pressor assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 7.00E+3nMAssay Description:Antagonist activity in phenoxybenzamine-treated rat by Pressor assayMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity in rat uterus by uterotonic assayMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity in rat uterus by uterotonic assayMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity in rat uterus by uterotonic assayMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair