null
SMILES OCCCc1nc(c([nH]1)-c1ccnc2[nH]cc(-c3cccc(NC(=O)C=C)c3)c12)-c1ccc(F)cc1
InChI Key InChIKey=WUDIBRLHJBOEBA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50266914
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£t T£bingen
Curated by ChEMBL
Eberhard Karls Universit£t T£bingen
Curated by ChEMBL
Affinity DataKd: 3.40nMAssay Description:Binding affinity to wild-type human EGFR (669 to 1011 residues) expressed in bacterial system preincubated for 1 hr followed by 30 fold dilution meas...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£t T£bingen
Curated by ChEMBL
Eberhard Karls Universit£t T£bingen
Curated by ChEMBL
Affinity DataKd: 2nMAssay Description:Binding affinity to wild-type human EGFR (669 to 1011 residues) expressed in bacterial system incubated for 1 hrMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard Karls Universit£t T£bingen
Curated by ChEMBL
Eberhard Karls Universit£t T£bingen
Curated by ChEMBL
Affinity DataIC50: 214nMAssay Description:Inhibition of p38alpha MAPK (unknown origin) assessed as decrease in ATF2 phosphorylation at Thr69/71 at 1 uM after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Eberhard Karls Universit£t T£bingen
Curated by ChEMBL
Eberhard Karls Universit£t T£bingen
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human GST-tagged wild type EGFR ( 668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system prein...More data for this Ligand-Target Pair