null

SMILES Cc1n[nH]c2ccc(cc12)-c1nnc(NC[C@@H](N)Cc2ccc(cc2)C(F)(F)F)s1

InChI Key InChIKey=KRKDQSSYLDUOBP-HNNXBMFYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50312754   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 357nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 333nMAssay Description:Inhibition of human AKT1 in human MDA-MB-468 cells assessed as phosphorylation-mediated nuclear translocation of GFP-tagged FKHRL1 by fluorescence mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed