null

SMILES CC(C)[C@@H](Nc1nc2cc[nH]c(=O)c2c2cnccc12)C(F)(F)F

InChI Key InChIKey=DBPPYNQBKGUMSZ-CYBMUJFWSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50331809   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck& Co.

Curated by ChEMBL
LigandPNGBDBM50331809((R)-6-(1,1,1-trifluoro-3-methylbutan-2-ylamino)pyr...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Binding affinity to human ERG expressed in HEK cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ90MGPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck& Co.

Curated by ChEMBL
LigandPNGBDBM50331809((R)-6-(1,1,1-trifluoro-3-methylbutan-2-ylamino)pyr...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 in cell-free systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ90MGPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck& Co.

Curated by ChEMBL
LigandPNGBDBM50331809((R)-6-(1,1,1-trifluoro-3-methylbutan-2-ylamino)pyr...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant Jak2 (unknown origin) using biotinylated synthetic peptide substrate by homogeneous time resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D22034PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck& Co.

Curated by ChEMBL
LigandPNGBDBM50331809((R)-6-(1,1,1-trifluoro-3-methylbutan-2-ylamino)pyr...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D22034PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck& Co.

Curated by ChEMBL
LigandPNGBDBM50331809((R)-6-(1,1,1-trifluoro-3-methylbutan-2-ylamino)pyr...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of JAK2 expressed in human Du-145 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ90MGPubMed