null

SMILES NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(O)(=O)=O

InChI Key InChIKey=NDCUAPJVLWFHHB-UHNVWZDZSA-N

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50339145   

TargetCarbapenem-hydrolyzing beta-lactamase KPC()
Qpex Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50339145(CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant Escherichia coli KPC-2 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition and measured e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2377D7QPubMed
TargetOXA23 carbapenemase(Acinetobacter baumannii)
Qpex Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50339145(CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...)copy SMILEScopy InChI
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of Acinetobacter baumannii OXA-23 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every 10 ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2377D7QPubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel SA

Curated by ChEMBL
LigandPNGBDBM50339145(CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...)copy SMILEScopy InChI
Affinity DataKi:  7.70E+3nMAssay Description:Inhibition of Enterobacter cloacae beta-lactamase P99 after 5 seconds incubation with nitrocefin substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8DSVPubMed
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Qpex Biopharma, Inc.

Curated by ChEMBL
LigandPNGBDBM50339145(CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...)copy SMILEScopy InChI
Affinity DataKi: >4.00E+4nMAssay Description:Inhibition of recombinant Escherichia coli VIM-1 using nitrocefin as substrate preincubated for 10 mins followed by substrate addition measured every...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2377D7QPubMed
TargetBeta-lactamase(Pseudomonas aeruginosa (PAO1))
Novexel SA

Curated by ChEMBL
LigandPNGBDBM50339145(CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...)copy SMILEScopy InChI
Affinity DataIC50: 128nMAssay Description:Inhibition of Pseudomonas aeruginosa beta-lactamase AmpC assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8DSVPubMed
TargetMetallo-beta-lactamase type 2(Bacillus cereus)TBA
LigandPNGBDBM50339145(CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...)copy SMILEScopy InChI
Affinity DataIC50: 141nMMore data for this Ligand-Target Pair
In DepthDetails
TargetBeta-lactamase TEM(Escherichia coli)TBA
LigandPNGBDBM50339145(CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of bacterial Beta-lactamase TEM-1 (24 - 286) (unknown origin) expressed in Escherichia coli Transetta (DE3)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CX1PubMed
TargetBeta-lactamase(Enterobacter cloacae)
Novexel SA

Curated by ChEMBL
LigandPNGBDBM50339145(CHEMBL1689063 | trans-7-oxo-6-(sulfooxy)-1,6-diaza...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of Enterobacter cloacae beta-lactamase P99 assessed as nitrocefin hydrolysis after 5 mins enzyme-compound preincubationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8DSVPubMed