null

SMILES C[C@H](Nc1nc(Nc2cc(C)n[nH]2)c(F)cc1C#N)c1ccc(F)cc1

InChI Key InChIKey=SUNXHXDJOIXABJ-NSHDSACASA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50343725   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:Inhibition of JAK2 V617F mutant (unknown origin) using L-Ahx-IPTSPITTTYFFFKKK-COOH as substrate in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79FW6PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
AstraZeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of JAK3 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetLIM domain kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 151nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193Q2PubMed
TargetLIM domain kinase 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193Q2PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 302nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193Q2PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 6.61E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193Q2PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193Q2PubMed
TargetLIM domain kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193Q2PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 after 60 minMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95ZDPubMed
TargetLIM domain kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50343725((S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5...)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193Q2PubMed