null
SMILES CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H](CO)[C@H](O)CO)nc12
InChI Key InChIKey=KRIWIRSMQRQYJG-DLBZAZTESA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50347388
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of CDK9/cyclinT assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human CDK2 expressed in baculovirus infected Sf9 cells using Histone H1 as substrate incubated for 10 mins by scintillation counting me...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CDK4/cyclinD1 assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 3.55E+4nMAssay Description:Inhibition of CDK6/cyclinD1 assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of CAMKKbetaMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2/cyclinE assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of CDK1/cyclinB1 assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 15(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
TargetInsulin receptor-related protein(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of IRRMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of DYRK1AMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 3.11E+3nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of CK1More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Competitive reversible inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Competitive reversible inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Competitive reversible inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.55E+4nMAssay Description:Competitive reversible inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Competitive reversible inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Competitive reversible inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Imperial College London
Curated by ChEMBL
Imperial College London
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of CDK7/cyclinH/MAT1 assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair