null
SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1ccc(C)cc1
InChI Key InChIKey=DMZMMAPPHDCECB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50353441
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 1.50E+4nMAssay Description:Inhibition of STAT3 SH2 domain assessed as inhibition of STAT3 SH2-phosphotyrosine interaction after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataKi: 1.50E+4nMAssay Description:Inhibition of mouse STAT3 SH2 domain using fluorescent probe 5-carboxyfluorescein-GpYLPQTV-NH2 after 30 mins by fluorescence polarisation assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 1.55E+4nMAssay Description:Displacement of fluorescein-labeled phosphotyrosine-peptide derived from the interleukin-6 receptor subunit gp130 from the STAT3 after 15 mins by flu...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataKi: 1.55E+4nMAssay Description:Inhibition of STAT3 using fluorescent probe 5-carboxyfluorescein-GpYLPQTV-NH2 after 15 mins by fluorescence polarisation assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 1-alpha/beta(Homo sapiens (Human))
University of Toronto
Curated by ChEMBL
University of Toronto
Curated by ChEMBL
Affinity DataKi: >2.50E+4nMAssay Description:Displacement of radioligand from the STAT1 after 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 5B(Homo sapiens (Human))
University of Toronto
Curated by ChEMBL
University of Toronto
Curated by ChEMBL
Affinity DataKi: >2.50E+4nMAssay Description:Displacement of 5-carboxyfluorescein-labeled GpYLVLDKW from the STAT5b-SH2 domain after 15 mins by fluorescent polarization assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 1(Mus musculus)
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of mouse STAT1 using fluorescent probe 5-carboxyfluorescein-GpYLPQTV-NH2 after 30 mins by fluorescence polarisation assayMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of STAT3 (unknown origin) dimerization by EMSAMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of STAT3 DNA binding activity in mouse NIH/3T3 nuclear extract preincubated for 30 mins followed by [32P]hSIE addition measured after 30 m...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
Affinity DataIC50: 3.10E+4nMAssay Description:Competitive binding affinity to Stat3 SH2 domain (unknown origin) using 5-FAM-GpYLPQTV-NH2 as probe assessed as phosphopetide complex formation after...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Homo sapiens (Human))
University of Southern California
Curated by ChEMBL
University of Southern California
Curated by ChEMBL
In DepthDetails
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataKd: 2.74E+3nMAssay Description:Binding affinity to STAT3 SH2 in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFRMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of STAT3 in mouse NIH3T3/vSrc nuclear extract assessed as disruption of the Stat3-DNA complex pre-incubated for 30 mins by EMSA analysisMore data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 3(Mus musculus (mouse))
University of Toronto Mississauga
Curated by ChEMBL
University of Toronto Mississauga
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of STAT3 dimerization in v-Src transformed mouse NIH/3T3 cells overexpressing human EGFR assessed as suppression of STAT3-DNA interaction ...More data for this Ligand-Target Pair