null

SMILES Nc1nc(Nc2cc(ccc2F)N2CCOCC2)nn1-c1ccccn1

InChI Key InChIKey=GXJJTQDCWLONOL-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50355468   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Displacement of [33P]ATP from human recombinant FLT3 domain after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DZ08QQPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)copy SMILEScopy InChI
Affinity DataKi:  37nMAssay Description:Displacement of [33P]ATP from human recombinant c-KIT domain after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DZ08QQPubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)copy SMILEScopy InChI
Affinity DataKi:  440nMAssay Description:Inhibition of IRAK4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DZ08QQPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)copy SMILEScopy InChI
Affinity DataKi:  590nMAssay Description:Inhibition of JAK2 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DZ08QQPubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)copy SMILEScopy InChI
Affinity DataKi: >3.00E+3nMAssay Description:Inhibition of Aurora A by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DZ08QQPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)copy SMILEScopy InChI
Affinity DataIC50: 760nMAssay Description:Inhibition of human recombinant c-Kit by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6Z6RPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vertex Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50355468(CHEMBL1835743)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant FLT3 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6Z6RPubMed