null
SMILES CCn1n2c(nnc2cc(-c2cc(cc(F)c2C)C(=O)NC2CC2)c1=O)-c1c(F)cccc1Cl
InChI Key InChIKey=NIPDDLFKIMAGDA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50363309
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant P38alpha assessed as inhibition of GST-tagged ATF2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of P38alpha in human whole blood assessed as inhibition of TNF-alpha-induced IL-8 production incubated for 1 hr prior to TNFalpha challeng...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amgen Inc.
Curated by ChEMBL
Amgen Inc.
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of P38alpha in human whole blood assessed as inhibition of LPS-induced MK2 phosphorylation incubated for 30 mins prior to LPS challenge me...More data for this Ligand-Target Pair