null
SMILES CNCC[C@@H](Oc1ccccc1C)c1ccccc1
InChI Key InChIKey=VHGCDTVCOLNTBX-QGZVFWFLSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 43 hits for monomerid = 50366567
Affinity DataKi: 0.700nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Displacement of [3H]nisoxetine from Sprague-dawley rat NET by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Ability to inhibit reuptake of norepinephrine ([3H]NE) at norepinephrine transporter of rat parietal/occipital regionMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 43nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 77nMAssay Description:Ability to inhibit reuptake of serotonin ([3H]5-HT) at serotonin transporter of rat midbrianMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 708nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 1.40E+3nMAssay Description:Inhibition of [3H]- DA reuptake into rat striatal synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataKi: 1.45E+3nMAssay Description:Ability to inhibit reuptake of dopamine ([3H]DA) at dopamine transporter of rat striatumMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Hong Kong University of Science and Technology
Curated by ChEMBL
Hong Kong University of Science and Technology
Curated by ChEMBL
Affinity DataKi: 1.50E+3nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-dawley rat frontal cortex by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in JAR celsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [125I]RTI55 from DAT in Sprague-dawley rat striatum by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Neurocrine Biosciences, Inc.
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by patch-clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Displacement of [alpha,beta-3H(N)]-5-hydroxytryptamine from human cloned SERT expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Displacement of 3,4-[ring-2,5,6-3H]dihydroxyphenylethylamine from human cloned DAT expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant CYP32D6More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of norepinephrine uptake at human NET in human HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of serotonin uptake at human SERT in human HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of dopamine uptake at human DAT in human HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of [3H]norepinephrine uptake at human NET expressed in MDCK-Net6 cells by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human NETMore data for this Ligand-Target Pair
Affinity DataKd: 8.90nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter-hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataKd: 1.08E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataKd: 2nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
TargetKrueppel-like factor 10(Homo sapiens (Human))
Beth Israel Deaconess Medical Center
Curated by ChEMBL
Beth Israel Deaconess Medical Center
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human KLF10 expressed in human HeLa cells assessed as reduction in transcriptional activity after 24 hrs by CACCC-responsive promoter d...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Neurocrine Bioscience, Inc.
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Displacement of Levo[ring-2,5,6-3H]norepinephrine from human cloned NET expressed in HEK293 cells by microplate scintillation counterMore data for this Ligand-Target Pair