null
SMILES CCc1ccc(cc1)-c1ccc2N(C)S(=O)(=O)c3c[nH]nc3-c2c1
InChI Key InChIKey=ISXAVIPPPMJTPN-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50430289
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of aurora-B (unknown origin)More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FLAG-tagged unphosphorylated full length FAK expressed in baculovirus expression system incubated for 5 mins prior to 1000 uM of ...More data for this Ligand-Target Pair
3D Structure (crystal)TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Allosteric inhibition of FAK (unknown origin) using poly-(GT)-biotin and 0.5 uM of ATP preincubated for 5 mins measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Allosteric inhibition of FAK (unknown origin) using poly-(GT)-biotin and 1000 uM of ATP preincubated for 60 mins measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Akt1 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of Pyk2 (unknown origin)More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 6.40E+3nMAssay Description:Allosteric inhibition of FAK (unknown origin) using poly-(GT)-biotin and 1000 uM of ATP preincubated for 60 mins measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of human 6His-tagged unphosphorylated PYK2 (1 to 967) using Poly-(GT)-biotin as substrate by AlphaScreen assay in presence of [gamma-33P]A...More data for this Ligand-Target Pair
TargetProtein-tyrosine kinase 2-beta(Homo sapiens (Human))
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Takeda Pharmaceutical Company Ltd
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human GST-tagged phosphorylated full length PYK2 (1 to 967) using Poly-(GT)-biotin as substrate by HTRF analysis in presence of [gamma-...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of YES (unknown origin) using [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of MLK1 (unknown origin) using [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of MLCK (unknown origin) using [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of HGK (unknown origin) using [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of GCK (unknown origin) using [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of FYN (unknown origin) using [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of FGR (unknown origin) using [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of CHK2 (unknown origin) using [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human FAK using [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human FLAG-tagged unphosphorylated full length FAK expressed in baculovirus expression system incubated for 60 mins prior to 0.5 uM of ...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human FLAG-tagged unphosphorylated full length FAK expressed in baculovirus expression system incubated for 5 mins prior to 0.5 uM ATP ...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human GST-tagged phosphorylated full length FAK incubated for 60 mins prior to 1000 uM of ATP addition by HTRF analysisMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human GST-tagged phosphorylated full length FAK incubated for 5 mins prior to 1000 uM of ATP addition by HTRF analysisMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of human GST-tagged phosphorylated full length FAK incubated for 60 mins prior to 0.5 uM of ATP addition by HTRF analysisMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.63E+4nMAssay Description:Inhibition of human GST-tagged phosphorylated full length FAK incubated for 5 mins prior to 0.5 uM of ATP addition by HTRF analysisMore data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 880nMAssay Description:ATP-noncompetitive inhibition of human unphosphorylated FAK kinase domain (411 to 686) using Poly-(GT)-biotin as substrate incubated for 60 mins prio...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:ATP-noncompetitive inhibition of human unphosphorylated FAK kinase domain (411 to 686) using Poly-(GT)-biotin as substrate incubated for 5 mins prior...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 990nMAssay Description:ATP-noncompetitive inhibition of human unphosphorylated FAK kinase domain (411 to 686) using Poly-(GT)-biotin as substrate incubated for 60 mins prio...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:ATP-noncompetitive inhibition of human unphosphorylated FAK kinase domain (411 to 686) using Poly-(GT)-biotin as substrate incubated for 5 mins prior...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human FLAG-tagged unphosphorylated full length FAK expressed in baculovirus expression system incubated for 60 mins prior to 1000 uM of...More data for this Ligand-Target Pair
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
Affinity DataIC50: 960nMAssay Description:Allosteric inhibition of FAK (unknown origin) using poly-(GT)-biotin and 0.5 uM of ATP preincubated for 60 mins measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair