null

SMILES Cc1ccc(cc1)-c1nn(C)c2nc(=O)n(C)c(=O)c2n1

InChI Key InChIKey=ADLBKNFHIOUYGV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50438910   

TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)copy SMILEScopy InChI
Affinity DataEC50:  290nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017ZBPubMed
TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of APE-1 (unknown origin) using double-stranded AP-site containing DNA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N017ZBPubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SIRT2 using biotin labeled histone H4 peptide with an acetylated lysine 4 as substrate measured after 1 hr by luminescence analys...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)copy SMILEScopy InChI
Affinity DataIC50: 40nMpH: 7.0Assay Description:Mtb PDH (Lpd+DlaT+AceE) is provided by Dr. Bryk Ruslana. The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HX1BGCUS Patent
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Guru Jambheshwar University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of human SIRT1 using biotinylated peptide with an acetylated FLAG sequence as substrate measured after 3 hr in presence of NAD+ by TR-FRET...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QTWPubMed
TargetDihydrolipoyl dehydrogenase(Mycobacterium tuberculosis)
Academia Sinica

US Patent
LigandPNGBDBM50438910(CHEMBL1450796 | US9073941, 618)copy SMILEScopy InChI
Affinity DataIC50: 40nMpH: 7.0Assay Description:The assay was performed in a manner similar to that described in Bryk et al., Biochemistry (2010) 49:1616-1627 and modified for an online robotics sc...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HX1BGCUS Patent