null

SMILES CN1CCN(Cc2ccc(cc2)-c2cnc3[nH]cc(-c4ccc5[nH]ccc5c4)c3c2)CC1

InChI Key InChIKey=QKKIWEILHCXECO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50441567   

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 307nMAssay Description:Inhibition of wild type human IGF1R by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2639TBBPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 257nMAssay Description:Inhibition of wild type human IKKb by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 217nMAssay Description:Inhibition of wild type human TRKB by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 201nMAssay Description:Inhibition of wild type human SGK1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetInsulin receptor(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of wild type human IR by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 177nMAssay Description:Inhibition of wild type human c-MET by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetProtein delta homolog 1(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of human wild type DLK by qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetAurora kinase B(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 123nMAssay Description:Inhibition of wild type human Aurora kinase B by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 111nMAssay Description:Inhibition of wild type human ROCK2 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetAurora kinase A(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 108nMAssay Description:Inhibition of wild type human Aurora kinase A by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Inhibition of wild type human TRKA by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human wild type LRRK2 by qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 6.80nMAssay Description:Inhibition of wild type human ABL1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of wild type human FLT3 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetMitogen-activated protein kinase kinase kinase 11(Mus musculus)
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 460nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetProtein delta homolog 1(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataKd:  70nMAssay Description:Binding affinity to human wild type DLK by qPCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of MLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of MLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of wild type human CDK1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of wild type human ROCK1 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 731nMAssay Description:Inhibition of wild type human SYK by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetMitogen-activated protein kinase kinase kinase 2(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 661nMAssay Description:Inhibition of wild type human MEKK2 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 591nMAssay Description:Inhibition of wild type human IKKa by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 560nMAssay Description:Inhibition of FLT3-L-stimulated wild type full length human FLT3 autophosphorylation expressed in MEF preincubated for 90 mins followed by FLT3-L sti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as inhibition of midazolam metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as inhibition of diclofenac metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 6.29E+3nMAssay Description:Inhibition of wild type human ERK2 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 5.05E+3nMAssay Description:Inhibition of wild type human ZAP70 by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B91DWUS Patent
TargetAurora kinase C(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:Inhibition of wild type human Aurora kinase C kinase by high throughput ATP-[33P] radiolabeled assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed