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SMILES CCOc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C

InChI Key InChIKey=XZLFLNWUBLMFQW-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50446179   

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Syntide 2 as substrate assessed as decrease in depletion of ATP after 90 mins by Kinase glo l...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J968BRPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK as substrate after 90 mins by Kinase glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J968BRPubMed
TargetcGMP-dependent protein kinase(Plasmodium falciparum)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)copy SMILEScopy InChI
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum PKG assessed as decrease in depletion of ATP by Kinase glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J968BRPubMed
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
Boehringer Ingelheim (Canada) Ltd.

LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23J3G91US Patent
TargetUncharacterized protein(Cryptosporidium parvum)
University of Washington Through its Center For Commercialization

US Patent
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BV7JN4US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
Boehringer Ingelheim (Canada) Ltd.

LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23J3G91US Patent
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair