null

SMILES CC(C)n1cnc2c(Nc3ccc(cc3)N3CCN(C)CC3)nc(N[C@H]3CCN(C3)C(=O)C=C)nc12

InChI Key InChIKey=GSLCJCBURXKYPH-FQEVSTJZSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50450874   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuxi AppTec

Curated by ChEMBL
LigandPNGBDBM50450874(CHEMBL4213741)copy SMILEScopy InChI
Affinity DataKi:  164nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2CJZPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuxi AppTec

Curated by ChEMBL
LigandPNGBDBM50450874(CHEMBL4213741)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A549 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by san...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2CJZPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuxi AppTec

Curated by ChEMBL
LigandPNGBDBM50450874(CHEMBL4213741)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of EGFR T790M/L858R double mutant phosphorylation in human H1975 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2CJZPubMed