null

SMILES Cc1noc(n1)[C@@H]1CCC(=O)N1c1cc(F)c(cc1F)-c1noc(n1)C(F)(F)F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 504529   

TargetHistone deacetylase 6(Homo sapiens (Human))TBA
LigandPNGBDBM504529((S)-1-(2,5-Difluoro-4-(5-(trifluoromethyl)-1,2,4-o...)copy SMILES
Affinity DataIC50: 3.90nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DN485ZUS Patent
TargetHistone deacetylase 8(Homo sapiens (Human))TBA
LigandPNGBDBM504529((S)-1-(2,5-Difluoro-4-(5-(trifluoromethyl)-1,2,4-o...)copy SMILES
Affinity DataIC50: 8.30E+3nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DN485ZUS Patent
TargetHistone deacetylase 5(Homo sapiens (Human))TBA
LigandPNGBDBM504529((S)-1-(2,5-Difluoro-4-(5-(trifluoromethyl)-1,2,4-o...)copy SMILES
Affinity DataIC50: 7nMAssay Description:HDAC5 reagents: N-terminal GST tagged HDAC5 was purchased from BPS Bioscience [catalog #50045]. Assays were performed with buffer containing 20 mM HE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DN485ZUS Patent
TargetHistone deacetylase 1(Homo sapiens (Human))TBA
LigandPNGBDBM504529((S)-1-(2,5-Difluoro-4-(5-(trifluoromethyl)-1,2,4-o...)copy SMILES
Affinity DataIC50: 1.10E+3nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DN485ZUS Patent