null
SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCCN(C)CC2)cc1
InChI Key InChIKey=HYUGTGGDEAGXJP-HRNNMHKYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50469353
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 0.430nMAssay Description:Inhibition of MERTK (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 3.90nMAssay Description:Inhibition of TYRO3 (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Inhibition of FLT3 (unknown origin) using 5'-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Inhibition of AXL (unknown origin) using 5'-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of N-terminal GST-tagged human TYRO3 cytoplasmic domain (453 to 890 end residues) expressed in baculovirus expression system using fluorec...More data for this Ligand-Target Pair
TargetSTE20-like serine/threonine-protein kinase(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of N-terminal GST-tagged full length human SLK (1 to 1152 end residues) expressed in baculovirus expression system using fluorecence-label...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal GST-tagged human KIT cytoplasmic domain (544 to 976 end residues) expressed in baculovirus expression system using fluorecen...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of MERTK in human 697 cells assessed as reduction in phosphorylated MERTK level preincubated for 1 hr followed by pervanadate phopshatase ...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of FLT3 (unknown origin) using 5'-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 9.10nMAssay Description:Inhibition of TYRO3 (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of N-terminal GST-tagged human FLT3 cytoplasmic domain (564 to 993 end residues) expressed in baculovirus expression system using fluorece...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-tagged human MERTK cytoplasmic domain (528 to 999 end residues) expressed in baculovirus expression system using fluorec...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of MERTK (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of AXL (unknown origin) using 5'-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Inhibition of N-terminal GST-tagged human TRKC cytoplasmic domain (456 to 825 end residues) expressed in baculovirus expression system using fluorece...More data for this Ligand-Target Pair
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal GST-tagged full length human NuaK1 (1 to 661 end residues) expressed in baculovirus expression system using fluorecence-labe...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of FLT3 in human SEM cells assessed as reduction in phosphorylated FLT3 level preincubated for 1 hr followed by pervanadate phopshatase in...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST-tagged AXL (464 to 885 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-tagged MERTK (528 to 999 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of N-terminal GST-tagged FLT3 (564 to 993 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of N-terminal GST-tagged TYRO3 (453 to 890 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of N-terminal GST-tagged TRKA (436 to 790 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 8.40nMAssay Description:Inhibition of N-terminal GST-tagged TRKC (456 to 825 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of N-terminal GST-tagged HGK (1 to 328 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Inhibition of N-terminal GST-tagged TNIK (1 to 314 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal GST-tagged TRKB (456 to 822 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of N-terminal GST-tagged MELK (1 to 493 residues) (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of N-terminal GST-tagged full length human QIK (1 to 926 end residues) expressed in baculovirus expression system using fluorecence-labele...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal GST-tagged human AXL cytoplasmic domain (464 to 885 end residues) expressed in baculovirus expression system using fluorecen...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
UNC Eshelman School of Pharmacy
Curated by ChEMBL
UNC Eshelman School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 859nMAssay Description:Inhibition of AXL in human A549 cells assessed as reduction in phosphorylated AXL level preincubated for 1 hr followed by pervanadate phopshatase inh...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of N-terminal GST-tagged human TRKA cytoplasmic domain (436 to 790 end residues) expressed in baculovirus expression system using fluorece...More data for this Ligand-Target Pair