null

SMILES CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1F

InChI Key InChIKey=VYNISSRXDZYNKV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50484231   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50484231(CHEMBL1822068)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of B-Raf V600E mutant-mediated Erk phosphorylation in human MALME-3M cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP5648PubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50484231(CHEMBL1822068)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full-length B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP5648PubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50484231(CHEMBL1822068)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length B-Raf V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7CX8PubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50484231(CHEMBL1822068)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of B-Raf V600E mutant-mediated Erk phosphorylation in human MALME-3M cells after 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H134VMPubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50484231(CHEMBL1822068)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Inhibition of B-Raf V600E mutant-mediated Erk phosphorylation in human A375 cells after 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H134VMPubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50484231(CHEMBL1822068)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length human B-Raf V600E mutant expressed in baculovirus infected insect cells assessed as [gamma-33P]incorporation into MEK after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H134VMPubMed