null
SMILES COC[C@H]1Cn2cc(nc2C(=O)N1Cc1ccc(F)c(F)c1)-c1nc(Nc2ccnn2C)ncc1C
InChI Key InChIKey=HVIGNZUDBVLTLU-MRXNPFEDSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50505988
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant full length human His-tagged CDK5/p35 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using ERKtide as substrate preincubated for 20 mins followed by substrate addition in presence...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
AstraZeneca
Curated by ChEMBL
AstraZeneca
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant full length human His-tagged ARK5 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
AstraZeneca
Curated by ChEMBL
AstraZeneca
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full length C-terminal His6-tagged Cdk2/human full length N-terminal GST-tagged Cyclin E expressed in baculovirus infected Sf21 i...More data for this Ligand-Target Pair
Affinity DataKd: 0.100nMAssay Description:Binding affinity to non-phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using ERKtide as substrate preincubated for 20 mins followed by substrate addition in presence...More data for this Ligand-Target Pair
Affinity DataKd: 0.0501nMAssay Description:Binding affinity to MEK-activated phosphorylated biotinylated ERK2 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant full length human GST/His-tagged CDK5/p25 expressed in baculovirus expression systemMore data for this Ligand-Target Pair