null
SMILES C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2
InChI Key InChIKey=OEBIHOVSAMBXIB-SJKOYZFVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 44 hits for monomerid = 50507492
Affinity DataIC50: 2.70nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:The compound was evaluated for its binding affinity against wild type scytalone dehydratase (SD)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS [D2033N](Homo sapiens (Human))
Array BioPharma Inc.
US Patent
Array BioPharma Inc.
US Patent
Affinity DataIC50: 3.60nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Homo sapiens (Human))
Array BioPharma Inc.
US Patent
Array BioPharma Inc.
US Patent
Affinity DataIC50: 0.5nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 0.980nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) using poly-EAY peptide as substrate in presence of gamma-33ATP by LanthaScreen assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) using poly-EAY peptide as substrate in presence of gamma-33ATP by LanthaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Homo sapiens (Human))
Array BioPharma Inc.
US Patent
Array BioPharma Inc.
US Patent
Affinity DataIC50: 20.4nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS [L2026M](Homo sapiens (Human))
Array BioPharma Inc.
US Patent
Array BioPharma Inc.
US Patent
Affinity DataIC50: 3.60nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS [D2033N](Homo sapiens (Human))
Array BioPharma Inc.
US Patent
Array BioPharma Inc.
US Patent
Affinity DataIC50: 0.5nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 9.30nMAssay Description:Inhibition of wildtype TRKA (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 40 mi...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Inhibition of TRKA GS95R mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type TrkC (unknown origin) using poly(Glu: Tyr) as substrate preincubated for 15 mins followed by substrate addition and further i...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type TrkA (unknown origin) using poly(Glu: Tyr) as substrate preincubated for 15 mins followed by substrate addition and further i...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type TrkB (unknown origin) using poly(Glu: Tyr) as substrate preincubated for 15 mins followed by substrate addition and further i...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type TrKA (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type TrKB (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type TrKC (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of TrKA G595R mutant (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 9.80nMAssay Description:Inhibition of TrKA G667C mutant (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of TrKA G595R mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of TrKA G667C mutant (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of TrKC (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 274nMAssay Description:Inhibition of ALK (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 120 mins in presence of 33P-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2 in human pooled liver microsomes using phenacetin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in human pooled liver microsomes using diclofenac as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 in human pooled liver microsomes using S-mephenytoin as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human pooled liver microsomes using dextromethorphan as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human pooled liver microsomes using midazolam and testosterone as substrate in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of wildtype human TRKA using poly (Glu,Tyr) 4:1 as substrate in presence of [gamma-33P]ATP by hotspot kinase assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Kinki University
Curated by ChEMBL
Kinki University
Curated by ChEMBL
TargetProto-oncogene tyrosine-protein kinase ROS [L2026M](Homo sapiens (Human))
Array BioPharma Inc.
US Patent
Array BioPharma Inc.
US Patent
Affinity DataIC50: 20.4nMAssay Description:The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...More data for this Ligand-Target Pair