null

SMILES C[C@H](Nc1cc(F)c(cc1Cl)S(=O)(=O)Nc1nccs1)c1cccnc1

InChI Key InChIKey=QTEMPVGNCZGUQZ-JTQLQIEISA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50530554   

TargetSodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50530554(CHEMBL4457973 | US11174268, Example 59)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z32344PubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Xenon Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50530554(CHEMBL4457973 | US11174268, Example 59)copy SMILEScopy InChI
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at PXR in human DPX2 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z32344PubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Xenon Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50530554(CHEMBL4457973 | US11174268, Example 59)copy SMILEScopy InChI
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at PXR in human DPX2 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z32344PubMed
TargetSodium channel protein type 8 subunit alpha/subunit beta-1(Homo sapiens (Human))
Xenon Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50530554(CHEMBL4457973 | US11174268, Example 59)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human full length Nav1.6 co-expressed with human SCN1B in HEK293 cells measured after 20 mins at -45 mV holding potential b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z32344PubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50530554(CHEMBL4457973 | US11174268, Example 59)copy SMILEScopy InChI
Affinity DataIC50: 1.72E+3nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QF8X18US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50530554(CHEMBL4457973 | US11174268, Example 59)copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QF8X18US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50530554(CHEMBL4457973 | US11174268, Example 59)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QF8X18US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50530554(CHEMBL4457973 | US11174268, Example 59)copy SMILEScopy InChI
Affinity DataIC50: 8.39E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QF8X18US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50530554(CHEMBL4457973 | US11174268, Example 59)copy SMILEScopy InChI
Affinity DataIC50: 387nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QF8X18US Patent